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LNP-2: Lipid Nanoparticles

From National Research Council Canada

Alternative titleLNP-2 : Nanoparticules de lipides
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DOIResolve DOI: https://doi.org/10.4224/crm.2025.lnp-2
AuthorSearch for: 1ORCID identifier: https://orcid.org/0000-0003-3307-8464; Search for: 1ORCID identifier: https://orcid.org/0000-0002-2480-6821; Search for: 1; Search for: 2; Search for: 2
Affiliation
  1. National Research Council of Canada
  2. Integrated Nanotherapeutics Inc., Burnaby BC, Canada
Format3D, Material
Material typeCalibration solution
SubjectCanadian reference material; LNP-2; hydrodynamic diameter
Abstract
The LNP-2 certified reference material (CRM) is a stable and homogeneous dispersion of siRNA loaded lipid nanoparticles (94% siRNA entrapment efficiency) of known provenance intended for methods development, inter-laboratory comparisons, verification of instrument performance, quality control, and general laboratory use to increase the confidence of size measurements of lipid-based as well as other soft nanoparticle formulations by dynamic light scattering. A single LNP-2 vial contains minimum 0.3 mL of lipid nanoparticle dispersion in pH 8, 48 mM Tris-HCl 10% sucrose buffer.
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PublisherNational Research Council of Canada
Copyright statement
  • © 2025 National Research Council of Canada
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References
View items (3)
  1. International Standard ISO 22412 2017: Particle size analysis — Dynamic light scattering (DLS) (1 February 2017). .
  2. ISO Guide 35:2017: Reference materials — Guidance for characterization and assessment of homogeneity and stability. (1 August 2017). .
  3. ‘Evaluation of Measurement Data — Guide to the Expression of Uncertainty in Measurement’, 2008. .
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CollectionCanadian Reference Materials and Methods
Record identifierce44d3ea-eb31-4d96-93a2-c4ab82beeff3
Record created2025-04-28
Record modified2025-04-28
Date modified: