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NEO-e: Calibration Solution Certified Reference Material for Neosaxitoxin

Alternative titleNEO-e : Matériau de référence certifié d’une solution d’étalonnage pour la néosaxitoxine
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DOIResolve DOI: https://doi.org/10.4224/crm.2026.neo-e.20251218
AuthorSearch for: 1; Search for: 1ORCID identifier: https://orcid.org/0000-0002-4850-5863; Search for: 1; Search for: 1ORCID identifier: https://orcid.org/0000-0001-5068-9879; Search for: 1ORCID identifier: https://orcid.org/0000-0002-7746-8432
Affiliation
  1. National Research Council Canada
Format3D, Material
Material typeCalibration solution
SubjectCanadian reference material; NEO-e; neosaxitoxin; saxitoxin analogue; algal toxins; cyanobacterial toxins
Abstract
CRM-NEO-e is a certified calibration solution designed for analytical method development and accurate quantitation of NEO. The concentration is suitable for preparing a dilution series for calibration of instrumentation, such as liquid chromatography with detection by post-column oxidation–fluorescence (LC–ox–FLD) or liquid chromatography–mass spectrometry (LC–MS).
Analytes
AnalyteQuantityValueExpanded uncertaintyUnitType
neosaxitoxinconcentration (15-30 °C)59.61.5µmol/Lcertified
saxitoxinconcentration (15-30 °C)0.06µmol/Linformation
Period of validity
  • Valid from 2026-04-02
  • 1 year from date of sale
Storage conditions
  • Temperature: 4 °C
Publication date
PublisherNational Research Council of Canada
Copyright statement
  • © 2026 National Research Council of Canada
Licence
Access condition
References
View items (8)
  1. Hall, Sherwood, Gary Strichartz, E. Moczydlowski, A. Ravindran, and P. B. Reichardt. ‘The Saxitoxins’. Marine Toxins, 29 January 1990, 29–65. .
  2. D’Agostino, Paul M., Michael J. Boundy, Tim D. Harwood, Wayne W. Carmichael, Brett A. Neilan, and Susanna A. Wood. ‘Re-Evaluation of Paralytic Shellfish Toxin Profiles in Cyanobacteria Using Hydrophilic Interaction Liquid Chromatography-Tandem Mass Spectrometry’. Toxicon 158 (February 2019): 1–7. .
  3. Laycock, Maurice V., Pierre Thibault, Stephen W. Ayer, and John A. Walter. ‘Isolation and Purification Procedures for the Preparation of Paralytic Shellfish Poisoning Toxin Standards’. Natural Toxins 2, no. 4 (July 1994): 175–83. .
  4. Dell’Aversano, Carmela, Philipp Hess, and Michael A. Quilliam. ‘Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry for the Analysis of Paralytic Shellfish Poisoning (PSP) Toxins’. Journal of Chromatography A 1081, no. 2 (July 2005): 190–201. .
  5. Van De Riet, Jeffrey, Ryan S Gibbs, Patricia M Muggah, Wade A Rourke, James D MacNeil, Michael A Quilliam, et al. ‘Liquid Chromatography Post-Column Oxidation (PCOX) Method for the Determination of Paralytic Shellfish Toxins in Mussels, Clams, Oysters, and Scallops: Collaborative Study’. Journal of AOAC INTERNATIONAL 94, no. 4 (1 July 2011): 1154–76. .
  6. Qiu, Jiangbing, Elliott J. Wright, Krista Thomas, Aifeng Li, Pearse McCarron, and Daniel G. Beach. ‘Semiquantitation of Paralytic Shellfish Toxins by Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry Using Relative Molar Response Factors’. Toxins 12, no. 6 (16 June 2020): 398. .
  7. Burton, Ian W., Michael A. Quilliam, and John A. Walter. ‘Quantitative 1H NMR with External Standards: Use in Preparation of Calibration Solutions for Algal Toxins and Other Natural Products’. Analytical Chemistry 77, no. 10 (26 March 2005): 3123–31. .
  8. ‘Evaluation of Measurement Data — Guide to the Expression of Uncertainty in Measurement’, 2008. .
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CollectionCanadian Reference Materials and Methods
Record identifier672c5237-699c-4a2b-a5d6-80661cf9f02a
Record created2026-04-17
Record modified2026-04-17

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