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CBIS-1: Certified Reference Material of dried, ground cannabis

From National Research Council Canada

Alternative titleCBIS-1 : Matériau de référence certifié de cannabis moulu et séché
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DOIResolve DOI: https://doi.org/10.4224/crm.2021.cbis-1
AuthorSearch for: 1; Search for: 1; Search for: 1ORCID identifier: https://orcid.org/0000-0002-3349-5535; Search for: 1ORCID identifier: https://orcid.org/0000-0002-2290-0101
Affiliation
  1. National Research Council Canada
Format3D, Material
Material typeMatrix material
SubjectCanadian reference material; CBIS-1; dried cannabis; Δ9-tetrahydrocannabinol (THC); Δ9-tetrahydrocannabinolic acid (THCA); cannabidiol (CBD); cannabidiolic acid (CBDA); cannabigerol (CBG); cannabigerolic acid (CBGA); cannabinol (CBN); cannabinolic acid (CBNA); cannabichromene (CBC); cannabichromenic acid (CBCA); tetrahydrocannabivarin (THCV); tetrahydrocannabivarinic acid (THCVA); cannabidivarin (CBDV); cannabidivarinic acid (CBDVA)
Abstract
CBIS-1 is a certified reference material (CRM) designed for use in method development, validation, and quality control for the analysis of cannabinoids in cannabis. While cannabinoid solution reference standards are appropriate for instrument calibration, matrix CRMs such as CBIS-1 can help validate entire methods, from sampling, extraction, clean-up, and instrumental analysis. Certified values for the mass fraction of cannabinoids in CBIS-1 have been established.
Analytes
View analytes
AnalyteQuantityValueExpanded uncertaintyUnitType
Δ⁹-tetrahydrocannabinol (THC)mass fraction48.96.4mg/gcertified
Δ⁹-tetrahydrocannabinolic acid (THCA)mass fraction1247mg/gcertified
total Δ⁹-tetrahydrocannabinol (total THC)mass fraction1589mg/gcertified
cannabidiol (CBD)mass fraction8.330.72mg/gcertified
cannabidiolic acid (CBDA)mass fraction23.01.0mg/gcertified
total cannabidiol (total CBD)mass fraction28.51.0mg/gcertified
cannabigerol (CBG)mass fraction1.780.18mg/gcertified
cannabigerolic acid (CBGA)mass fraction3.890.20mg/gcertified
cannabinol (CBN)mass fraction3.390.42mg/gcertified
cannabinolic acid (CBNA)mass fraction1.840.12mg/gcertified
cannabichromene (CBC)mass fraction1.020.08mg/gcertified
cannabichromenic acid (CBCA)mass fraction1.670.10mg/gcertified
tetrahydrocannabivarin (THCV)mass fraction0.2520.026mg/gcertified
tetrahydrocannabivarinic acid (THCVA)mass fraction0.4460.034mg/gcertified
cannabidivarin (CBDV)mass fraction0.04150.0038mg/gcertified
cannabidivarinic acid (CBDVA)mass fraction0.1260.008mg/gcertified
Publication date
PublisherNational Research Council Canada
Copyright statement
  • © 2021 National Research Council Canada
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References
View items (5)
  1. McRae, Garnet, and Jeremy E. Melanson. ‘Quantitative Determination and Validation of 17 Cannabinoids in Cannabis and Hemp Using Liquid Chromatography-Tandem Mass Spectrometry’. Analytical and Bioanalytical Chemistry 412, no. 27 (24 August 2020): 7381–93. .
  2. Mudge, Elizabeth M, and Paula N Brown. ‘Determination of Cannabinoids in Cannabis Sativa Dried Flowers and Oils by LC-UV: Single-Laboratory Validation, First Action 2018.10’. Journal of AOAC INTERNATIONAL 103, no. 2 (March 2020): 489–93. .
  3. Guide to the expression of uncertainty in measurement (GUM) (1 September 2008). .
  4. Meija, Juris, Garnet McRae, Christopher O. Miles, and Jeremy E. Melanson. ‘Thermal Stability of Cannabinoids in Dried Cannabis: A Kinetic Study’. Analytical and Bioanalytical Chemistry 414, no. 1 (8 January 2021): 377–84. .
  5. Veen, Adriaan M. H. van der. ‘Bayesian Analysis of Homogeneity Studies in the Production of Reference Materials’. Accreditation and Quality Assurance 22, no. 6 (2 November 2017): 307–19. .
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CollectionCanadian Reference Materials and Methods
Record identifier335aa529-82d3-4744-9c85-525dfe7e3ac0
Record created2021-03-31
Record modified2025-11-20
Date modified: