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hATX: Calibration Solution Certified Reference Material for Homoanatoxin-a

From National Research Council Canada

Alternative titlehATX: Matériau de référence certifié d’une solution d’étalonnage pour l’homoanatoxine-a
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DOIResolve DOI: https://doi.org/10.4224/crm.2024.hatx.20230928
AuthorSearch for: 1ORCID identifier: https://orcid.org/0000-0002-5680-2112; Search for: 1; Search for: 1ORCID identifier: https://orcid.org/0000-0002-4850-5863; Search for: 1ORCID identifier: https://orcid.org/0000-0003-1644-2121; Search for: 1ORCID identifier: https://orcid.org/0000-0002-7746-8432
Affiliation
  1. National Research Council Canada
Format3D, Material
SubjectCanadian reference material; homoanatoxin-a; hATX; cyanobacteria; cyanotoxin
Abstract
CRM-hATX is a certified calibration solution designed for analytical method development and accurate quantitation of hATX. The concentration is suitable for preparing a dilution series for calibration of instrumentation, such as liquid chromatography–mass spectrometry (LC–MS), as well as for spiking control samples for recovery experiments.
Analytes
AnalyteQuantityValueExpanded uncertaintyUnitType
homoanatoxin-amass fraction5.130.26µg/gcertified
homoanatoxin-amass concentration (15-30 °C)5.050.26µg/mLcertified
homoanatoxin-aconcentration (15-30 °C)28.21.4µmol/Lcertified
Publication date
PublisherNational Research Council of Canada
Copyright statement
  • © 2024 National Research Council of Canada
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References
View items (9)
  1. McCarron, Pearse, Cheryl Rafuse, Steven Scott, Janice Lawrence, Meghann R. Bruce, Erin Douthwright, Colleen Murphy, Michael Reith, and Daniel G. Beach. ‘Anatoxins from Benthic Cyanobacteria Responsible for Dog Mortalities in New Brunswick, Canada’. Toxicon 227 (May 2023): 107086. .
  2. Wood, Susanna A., Andrew I. Selwood, Andreas Rueckert, Patrick T. Holland, Juliet R. Milne, Kirsty F. Smith, Bronwyn Smits, Laura F. Watts, and Craig S. Cary. ‘First Report of Homoanatoxin-a and Associated Dog Neurotoxicosis in New Zealand’. Toxicon 50, no. 2 (August 2007): 292–301. .
  3. Skulberg, Olav M., Randi Skulberg, Wayne W. Carmichael, Rolf A. Andersen, Shigeki Matsunaga, and Richard E. Moore. ‘Investigations of a Neurotoxic Oscillatorialean Strain (Cyanophyceae) and Its Toxin. Isolation and Characterization of Homoanatoxin‐a’. Environmental Toxicology and Chemistry 11, no. 3 (March 1992): 321–29. .
  4. Beach, Daniel G., Lydia Zamlynny, Melanie MacArthur, and Christopher O. Miles. ‘Liquid Chromatography–High-Resolution Tandem Mass Spectrometry of Anatoxins, Including New Conjugates and Reduction Products’. Analytical and Bioanalytical Chemistry 415, no. 22 (29 July 2023): 5281–96. .
  5. D’Agostino, Paul M., Michael J. Boundy, Tim D. Harwood, Wayne W. Carmichael, Brett A. Neilan, and Susanna A. Wood. ‘Re-Evaluation of Paralytic Shellfish Toxin Profiles in Cyanobacteria Using Hydrophilic Interaction Liquid Chromatography-Tandem Mass Spectrometry’. Toxicon 158 (February 2019): 1–7. .
  6. Thomas, Krista, Dominik Wechsler, Yi-Min Chen, Sheila Crain, and Michael A Quilliam. ‘Analysis of Natural Toxins by Liquid Chromatography-Chemiluminescence Nitrogen Detection and Application to the Preparation of Certified Reference Materials’. Journal of AOAC INTERNATIONAL 99, no. 5 (1 September 2016): 1173–84. .
  7. Burton, Ian W., Michael A. Quilliam, and John A. Walter. ‘Quantitative 1H NMR with External Standards: Use in Preparation of Calibration Solutions for Algal Toxins and Other Natural Products’. Analytical Chemistry 77, no. 10 (26 March 2005): 3123–31. .
  8. Thomas, Krista, Andrew Selwood, Susanna Wood, Yi-Min Chen, Sheila Crain, John Walter, and Michael Quilliam. ‘ATX: Certified Calibration Solution for Anatoxin-a’. National Research Council of Canada, 1 March 2011. .
  9. ‘Evaluation of Measurement Data — Guide to the Expression of Uncertainty in Measurement’, 2008. .
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CollectionCanadian Reference Materials and Methods
Record identifier2a2ae741-09ad-43bb-9ca7-0b2402d1141b
Record created2024-12-04
Record modified2024-12-20
Date modified: